Barf, Tjeerd : rechercher sur Z-Library

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1

N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte fatty-acid binding protein (A-FABP) inhibitors

Tjeerd Barf, Fredrik Lehmann, Kristin Hammer, Saba Haile, Eva Axen, Carmen Medina, Jonas Uppenberg, Stefan Svensson, Lena Rondahl, Thomas Lundbäck

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 396 KB

english, 2009

2

Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target

Fredik Lehmann, Saba Haile, Eva Axen, Carmen Medina, Jonas Uppenberg, Stefan Svensson, Thomas Lundbäck, Lena Rondahl, Tjeerd Barf

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 308 KB

english, 2004

3

Arylsulfonamidothiazoles as a New Class of Potential Antidiabetic Drugs. Discovery of Potent and Selective Inhibitors of the 11β-Hydroxysteroid Dehydrogenase Type 1

Barf, Tjeerd, Vallgårda, Jerk, Emond, Rikard, Häggström, Charlotta, Kurz, Guido, Nygren, Alf, Larwood, Vivienne, Mosialou, Erifili, Axelsson, Kent, Olsson, Rolf, Engblom, Lars, Edling, Naimie, Rönquis

Journal:

Journal of Medicinal Chemistry

Année:

2002

Langue:

english

Fichier:

PDF, 62 KB

english, 2002

4

Characterization of Irreversible Kinase Inhibitors by Directly Detecting Covalent Bond Formation: A Tool for Dissecting Kinase Drug Resistance

Sabine Klüter , Dr. Jeffrey R. Simard , Dr. Haridas B. Rode, Dr. Christian Grütter, Dr. Vijaykumar Pawar, Dr. Hans C. A. Raaijmakers, Dr. Tjeerd A. Barf, Dr. Matthias Rabiller, Prof. Dr. Willem A. L.

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 702 KB

english, 2010

5

Inside Cover: Characterization of Irreversible Kinase Inhibitors by Directly Detecting Covalent Bond Formation: A Tool for Dissecting Kinase Drug Resistance (ChemBioChem 18/2010)

Sabine Klüter , Dr. Jeffrey R. Simard , Dr. Haridas B. Rode, Dr. Christian Grütter, Dr. Vijaykumar Pawar, Dr. Hans C. A. Raaijmakers, Dr. Tjeerd A. Barf, Dr. Matthias Rabiller, Prof. Dr. Willem A. L.

Journal:

Année:

2010

Fichier:

PDF, 643 KB

2010

6

Discovery of Inhibitors of Human Adipocyte Fatty Acid-Binding Protein, a Potential Type 2 Diabetes Target.

Fredik Lehmann, Saba Haile, Eva Axen, Carmen Medina, Jonas Uppenberg, Stefan Svensson, Thomas Lundbaeck, Lena Rondahl, Tjeerd Barf

Journal:

Année:

2004

Fichier:

PDF, 12 KB

2004

7

Substituted Benzylamino-6-(trifluoromethyl)pyrimidin-4(1H)-ones: A Novel Class of Selective Human A-FABP Inhibitors.

Rune Ringom, Eva Axen, Jonas Uppenberg, Thomas Lundbaeck, Lena Rondahl, Tjeerd Barf

Journal:

Année:

2004

Fichier:

PDF, 14 KB

2004

8

Substituted benzylamino-6-(trifluoromethyl)pyrimidin-4(1H)-ones: a novel class of selective human A-FABP inhibitors

Rune Ringom, Eva Axen, Jonas Uppenberg, Thomas Lundbäck, Lena Rondahl, Tjeerd Barf

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 361 KB

english, 2004

9

Structure-based lead identification of ATP-competitive MK2 inhibitors

Tjeerd Barf, Allard Kaptein, Sander de Wilde, Ruud van der Heijden, Richard van Someren, Dennis Demont, Carsten Schultz-Fademrecht, Judith Versteegh, Mario van Zeeland, Nicole Seegers, Bert Kazemier,

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 656 KB

english, 2011

10

5-(Sulfonyl)oxy-tryptamines and ethylamino side chain restricted derivatives. Structure–affinity relationships for h5-HT1B and h5-HT1D receptors

Tjeerd Barf, Håkan Wikström, Petrus J. Pauwels, Christiane Palmier, Stephanie Tardif, Max Lundmark, Staffan Sundell

Journal:

Bioorganic & Medicinal Chemistry

Année:

1998

Langue:

english

Fichier:

PDF, 248 KB

english, 1998

11

Self-assembling chiral metallo-clefts; synthesis and molecular structure of N,N′-bis(12H-benzo[α]xanthen-12-ylidene)-1,2-ethanediamine zinc(II)-dichloride complex

Tjeerd Barf, Johan F. G. A. Jansen, Fré van Bolhuis, Ben L. Feringa, Anthony L. Spek

Journal:

Recueil des Travaux Chimiques des Pays-Bas

Année:

1993

Langue:

english

Fichier:

PDF, 815 KB

english, 1993

12

Irreversible Protein Kinase Inhibitors: Balancing the Benefits and Risks

Barf, Tjeerd, Kaptein, Allard

Journal:

Journal of Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 9.37 MB

english, 2012

13

Potential anxiolytic properties of R-(+)-8-OSO2CF3-PAT, a 5-HT1A receptor agonist

Tjeerd Barf, S.Mechiel Korte, Gerdien Korte-Bouws, Clas Sonesson, Geert Damsma, Béla Bohus, Håkan Wikström

Journal:

European Journal of Pharmacology

Année:

1996

Langue:

english

Fichier:

PDF, 737 KB

english, 1996

14

Investigations with GMC2021 in experimental models predictive of antimigraine activity and coronary side-effect potential

Pramod R. Saxena, Peter De Vries, Jan P.C. Heiligers, Antoinette Maassen VanDenBrink, Willem A. Bax, Tjeerd Barf, Håkan Wikström

Journal:

European Journal of Pharmacology

Année:

1996

Langue:

english

Fichier:

PDF, 928 KB

english, 1996

15

Active site variability of type 1 11β-hydroxysteroid dehydrogenase revealed by selective inhibitors and cross-species comparisons

Malin Hult, Naeem Shafqat, Björn Elleby, Doreen Mitschke, Stefan Svensson, Margareta Forsgren, Tjeerd Barf, Jerk Vallgårda, Lars Abrahmsen, Udo Oppermann

Journal:

Molecular and Cellular Endocrinology

Année:

2006

Langue:

english

Fichier:

PDF, 569 KB

english, 2006

16

Synthesis and Biological Activity of a Novel Class of Small Molecular Weight Peptidomimetic Competitive Inhibitors of Protein Tyrosine Phosphatase 1B

Larsen, Scott D., Barf, Tjeerd, Liljebris, Charlotta, May, Paul D., Ogg, Derek, O'Sullivan, Theresa J., Palazuk, Barbara J., Schostarez, Heinrich J., Stevens, F. Craig, Bleasdale, John E.

Journal:

Journal of Medicinal Chemistry

Année:

2002

Langue:

english

Fichier:

PDF, 438 KB

english, 2002

17

5-HT 1D Receptor Agonist Properties of Novel 2-[5-[[(Trifluoromethyl)sulfonyl]oxy]indolyl]ethylamines and Their Use as Synthetic Intermediates

Barf, Tjeerd A., de Boer, Peter, Wikström, Håkan, Peroutka, Stephen J., Svensson, Kjell, Ennis, Michael D., Ghazal, Nabil B., McGuire, James C., Smith, Martin W.

Journal:

Journal of Medicinal Chemistry

Année:

1996

Langue:

english

Fichier:

PDF, 252 KB

english, 1996

18

Synthesis and Evaluation of Pharmacological and Pharmacokinetic Properties of Monopropyl Analogs of 5-, 7-, and 8-[[(Trifluoromethyl)sulfonyl]oxy]-2-aminotetralins: Central Dopamine and Serotonin Receptor Activity

Sonesson, Clas, Barf, Tjeerd, Nilsson, Jonas, Dijkstra, Durk, Carlsson, Arvid, Svensson, Kjell, Smith, Martin W., Martin, Iain J., Duncan, J. Neil

Journal:

Journal of Medicinal Chemistry

Année:

1995

Langue:

english

Fichier:

PDF, 1.40 MB

english, 1995

19

Direct and two-step bioorthogonal probes for Bruton's tyrosine kinase based on ibrutinib: a comparative study

Liu, Nora, Hoogendoorn, Sascha, van de Kar, Bas, Kaptein, Allard, Barf, Tjeerd, Driessen, Christoph, Filippov, Dmitri V., van der Marel, Gijsbert A., van der Stelt, Mario, Overkleeft, Herman S.

Journal:

Organic & Biomolecular Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 1.20 MB

english, 2015

20

Acalabrutinib (ACP-196): A covalent Bruton tyrosine kinase (BTK) inhibitor with a differentiated selectivity and in vivo potency profile

Barf, Tjeerd, Covey, Todd, Izumi, Raquel, van de Kar, Bas, Gulrajani, Michael, van Lith, Bart, van Hoek, Maaike, de Zwart, Edwin, Mittag, Diana, Demont, Dennis, Verkaik, Saskia, Krantz, Fanny, Pearson

Journal:

Journal of Pharmacology and Experimental Therapeutics

Année:

2017

Langue:

english

Fichier:

PDF, 868 KB

english, 2017

21

Potency and Selectivity of BTK Inhibitors in Clinical Development for B-Cell Malignancies

Kaptein, Allard, de Bruin, Gerjan, Hoek, Maaike Emmelot-van, van de Kar, Bas, de Jong, Anouk, Gulrajani, Michael, Demont, Dennis, Covey, Todd, Mittag, Diana, Barf, Tjeerd

Journal:

Clinical Lymphoma Myeloma and Leukemia

Année:

2019

Langue:

english

Fichier:

PDF, 94 KB

english, 2019